NASA scientists studying the origin of life have reproduced uracil, cytosine, and thymine, three key components of our hereditary material, in the laboratory. They discovered that an ice sample containing pyrimidine exposed to ultraviolet radiation under space-like conditions produces these essential ingredients of life.
Pyrimidine is a ring-shaped molecule made up of carbon and nitrogen and is the central structure for uracil, cytosine, and thymine, which are all three part of a genetic code found in ribonucleic (RNA) and deoxyribonucleic acids (DNA). RNA and DNA are central to protein synthesis, but also have many other roles.
“We have demonstrated for the first time that we can make uracil, cytosine, and thymine, all three components of RNA and DNA, non-biologically in a laboratory under conditions found in space,” said Michel Nuevo, research scientist at NASA’s Ames Research Center, Moffett Field, California. “We are showing that these laboratory processes, which simulate conditions in outer space, can make several fundamental building blocks used by living organisms on Earth.”
An ice sample is deposited on a cold (approximately –440 degrees Fahrenheit) substrate in a chamber, where it is irradiated with high-energy ultraviolet (UV) photons from a hydrogen lamp. The bombarding photons break chemical bonds in the ices and break down the ice’s molecules into fragments that then recombine to form new compounds, such as uracil, cytosine, and thymine.
NASA Ames scientists have been simulating the environments found in interstellar space and the outer Solar System for years. During this time, they have studied a class of carbon-rich compounds, called polycyclic aromatic hydrocarbons (PAHs), that have been identified in meteorites, and which are the most common carbon-rich compound observed in the universe. PAHs typically are structures based on several six-carbon rings that resemble fused hexagons, or a piece of chicken wire.
The molecule pyrimidine is found in meteorites, although scientists still do not know its origin. It may be similar to the carbon-rich PAHs, in that it may be produced in the final outbursts of dying, giant red stars, or formed in dense clouds of interstellar gas and dust.
“Molecules like pyrimidine have nitrogen atoms in their ring structures, which makes them somewhat wimpy. As a less stable molecule, it is more susceptible to destruction by radiation, compared to its counterparts that don’t have nitrogen,” said Scott Sandford, a space science researcher at Ames. “We wanted to test whether pyrimidine can survive in space, and whether it can undergo reactions that turn it into more complicated organic species, such as the nucleobases uracil, cytosine, and thymine.”